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Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. P-selectin glycoprotein ligand-1 is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin. ==Posttranslational modification== PSGL-1 protein requires two distinct posttranslational modifications to gain its selectin binding activity: * sulfation of tyrosines * the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「P-selectin glycoprotein ligand-1」の詳細全文を読む スポンサード リンク
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